|
KMID : 0880220130510060836
|
|
Journal of Microbiology
2013 Volume.51 No. 6 p.836 ~ p.843
|
|
|
Cyclic Dipeptides from Lactic Acid Bacteria Inhibit Proliferation of the Influenza A Virus
|
|
Kwak Min-Kyu
Rui Liu
Kwon Jun-Oh
Kim Min-Kyu
Andrew HyoungJin Kim
Sa-Ouk Kang
|
|
|
Abstract
|
|
|
|
We isolated Lactobacillus plantarum LBP-K10 from the traditional Korean fermented food kimchi. When organic acids were removed, the culture filtrate of this isolate showed high antiviral activity (measured using a plaque-forming assay) against the influenza A (H3N2) virus. Two fractions that were active against influenza A virus were purified from the culture filtrate using a C18 column with high-performance liquid chromatography. These active fractions were crystallized and identified to be the cyclic dipeptides cis-cyclo (L-Leu-L-Pro) and cis-cyclo(L-Phe-L-Pro) using gas chromatography-mass spectrometry; this identification was confirmed by X-ray crystallography. These cyclic dipeptides were identified in the culture filtrate of other lactic acid bacteria, including Lactobacillus spp., Leuconostoc spp., Weissella spp., and Lactococcus lactis.
|
|
|
KEYWORD
|
|
|
Lactobacillus plantarum LBP-K10, culture filtrate, cis-cyclo(L-Leu-L-Pro), cis-cyclo(L-Phe-L-Pro), influenza A virus, antiviral activity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|